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There are 11 twelve-letter words containing 2D, 3E, M and O

COMMANDEEREDcommandeered v. Simple past tense and past participle of commandeer.
COMMANDEER v. to compel to perform military service.
COMPREHENDEDcomprehended v. Simple past tense and past participle of comprehend.
comprehended adj. Understood.
comprehended adj. Included; comprised; contained.
DECOMPRESSEDdecompressed v. Simple past tense and past participle of decompress.
DECOMPRESS v. to release from pressure or compression.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DENDROMETERSdendrometers n. Plural of dendrometer.
DENDROMETER n. an instrument for measuring trees.
DISEMBOWELEDdisemboweled v. Simple past tense and past participle of disembowel.
DISEMBOWEL v. to take out the bowels of.
DISEMPOWEREDdisempowered v. Simple past tense and past participle of disempower.
DISEMPOWER v. to deprive of power; to divest of strength.
ENDODERMISESENDODERMIS n. a close-set sheath, one cell thick, enclosing the central cylinder in plants.
MEDDLESOMELYmeddlesomely adv. In a meddlesome manner.
MEDDLESOME adv. given to meddling.
MISDEVELOPEDmisdeveloped v. Simple past tense and past participle of misdevelop.
MISDEVELOP v. to develop wrongly.
PRECONDEMNEDprecondemned v. Simple past tense and past participle of precondemn.
PRECONDEMN v. to condemn beforehand.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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