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There are 8 twelve-letter words containing 2D, 3E, H and M

COMPREHENDEDcomprehended v. Simple past tense and past participle of comprehend.
comprehended adj. Understood.
comprehended adj. Included; comprised; contained.
DEMETHYLATEDdemethylated v. Simple past tense and past participle of demethylate.
demethylated adj. (Chemistry) That has been subjected to demethylation.
DEPHLEGMATEDdephlegmated v. Simple past tense and past participle of dephlegmate.
DEPHLEGMATE v. to distill something, such as alcohol.
HAMMERHEADEDhammerheaded adj. Alternative form of hammer-headed.
hammer-headed adj. Having a head in the shape of a hammer.
hammer-headed adj. (Idiomatic) stupid, ignorant.
METALDEHYDESMETALDEHYDE n. a polymer of acetaldehyde.
MUDDLEHEADEDmuddleheaded adj. Alternative form of muddle-headed.
muddle-headed adj. Characterized by vague or confused thinking: foolish, dull-witted, semi-conscious.
MUDDLEHEADED adj. mentally confused.
SEMIDETACHEDsemidetached adj. Alternative spelling of semi-detached.
semidetached n. Alternative spelling of semi-detached.
semi-detached adj. Of a house: joined to another one on one side, having one shared wall.
UNDERWHELMEDunderwhelmed v. Simple past tense and past participle of underwhelm.
UNDERWHELM v. to fail to impress.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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