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There are 11 twelve-letter words containing 2D, 4E and S

DECEREBRISEDDECEREBRISE v. to deprive of the cerebrum, also DECEREBRIZE.
DEGENDERIZESdegenderizes v. Third-person singular simple present indicative form of degenderize.
DEJECTEDNESSdejectedness n. The state or quality of being dejected.
DEJECTEDNESS n. the state of being dejected.
DEMENTEDNESSdementedness n. The quality of being demented.
DEMENTEDNESS n. the state of being demented.
DEPENDENCIESdependencies n. Plural of dependency.
DEPENDENCY n. the state of being dependent, also DEPENDANCE, DEPENDANCY, DEPENDENCE.
DEREGISTEREDderegistered v. Simple past tense and past participle of deregister.
DEREGISTER v. to remove from a register.
DESEGREGATEDdesegregated v. Simple past tense and past participle of desegregate.
DESEGREGATE v. to eliminate segregation in.
DESERVEDNESSdeservedness n. The state or quality of being deserved.
DESERVEDNESS n. the state of being deserved.
EXTENDEDNESSextendedness n. The condition of being extended; extension.
EXTENDEDNESS n. the state of being extended.
SLEEPYHEADEDSLEEPYHEADED adj. given to sleep.
UNDERSTEEREDundersteered v. Simple past tense and past participle of understeer.
UNDERSTEER v. to turn less sharply than the driver intends.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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