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There are 10 twelve-letter words containing 2D, 4E and I

DECEREBRISEDDECEREBRISE v. to deprive of the cerebrum, also DECEREBRIZE.
DECEREBRIZEDdecerebrized v. Simple past tense and past participle of decerebrize.
DECEREBRIZE v. to deprive of the cerebrum, also DECEREBRISE.
DEGENDERIZEDdegenderized v. Simple past tense and past participle of degenderize.
DEGENDERIZESdegenderizes v. Third-person singular simple present indicative form of degenderize.
DEPENDENCIESdependencies n. Plural of dependency.
DEPENDENCY n. the state of being dependent, also DEPENDANCE, DEPENDANCY, DEPENDENCE.
DEREGISTEREDderegistered v. Simple past tense and past participle of deregister.
DEREGISTER v. to remove from a register.
FEEBLEMINDEDfeebleminded adj. Alternative spelling of feeble-minded.
feeble-minded adj. Weak in intellectual power; lacking firmness or constancy; lacking intelligence.
FEEBLEMINDED adj. mentally deficient.
FIDDLEDEEDEEfiddledeedee interj. (Colloquial, dated) nonsense; rubbish.
FIDDLEDEEDEE interj. an exclamation of impatience, disbelief, or disagreement, also FIDDLEDEDEE.
INDEPENDENCEindependence n. The quality or state of being independent; lack of dependence; the state of not being reliant on, or…
independence n. The state of having sufficient means for a comfortable livelihood.
Independence prop.n. A city in Missouri, United States and one of the two county seats of Jackson County.
REDETERMINEDredetermined v. Simple past tense and past participle of redetermine.
REDETERMINE v. to determine again.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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