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There are 15 ten-letter words containing D, 2I, 2O, R and S

CORTICOIDScorticoids n. Plural of corticoid.
CORTICOID n. any of the steroid hormones produced in the adrenal cortex, also CORTICOSTEROID.
DIORTHOSISdiorthosis n. (Obsolete) The act of setting a fracture or dislocation.
diorthosis n. A critical revision of a text.
DIORTHOSIS n. a critical revision of a text; any correction or adjustment.
DISPOSITORdispositor n. (Obsolete) A disposer.
dispositor n. (Obsolete, astrology) The planet that is lord of the sign where another planet is.
DISPOSITOR n. in astrology, a planet that disposes or controls another.
DISROOTINGdisrooting v. Present participle of disroot.
DISROOT v. to tear up the roots of, or by the roots.
DISTORTIONdistortion n. An act of distorting.
distortion n. A result of distorting.
distortion n. A misrepresentation of the truth.
DORMITIONSdormitions n. Plural of dormition.
DORMITION n. the act of sleeping; falling asleep.
ISOPRENOIDisoprenoid n. (Organic chemistry) Any compound formally derived from one or more isoprene units.
ISOPRENOID n. a type of chemical compound, featuring a hydrocarbon of the terpene group.
OPHIUROIDSophiuroids n. Plural of ophiuroid.
OPHIUROID n. a member of the Ophiura genus of brittle-stars or sand-stars, also OPHIURA, OPHIURAN, OPHIURID.
OSMIDROSISosmidrosis n. Body odour.
OSMIDROSIS n. the emission of ill-smelling sweat.
PRODIGIOUSprodigious adj. Very big in size or quantity; colossal, gigantic, huge.
prodigious adj. Extraordinarily amazing or exciting.
prodigious adj. Freakish; monstrous.
RIGWOODIESrigwoodies n. Plural of rigwoodie.
RIGWOODIE n. (Scots) a carthorse's backband, also RIGWIDDIE.
SCORPIOIDSscorpioids n. Plural of scorpioid.
SCORPIOID n. a scorpion; a scorpion-like animal.
SORORICIDEsororicide n. The killing of one’s sister.
sororicide n. A person who kills his or her sister.
SORORICIDE n. the killing of one's own sister.
STROBILOIDstrobiloid adj. Resembling a strobile.
STROBILOID adj. like a strobile, a scaly multiple fruit resulting from the ripening of an ament in certain plants.
VARIOLOIDSvarioloids n. Plural of varioloid.
VARIOLOID n. a disease resembling variola, smallpox.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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