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There is only one ten-letter word containing 2D, N, O, P, S and T

DESPONDENTdespondent adj. In low spirits from loss of hope or courage.
DESPONDENT adj. feeling or showing extreme discouragement.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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