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There are 17 ten-letter words containing 2D, 2E, 2R and S

ADDRESSERSaddressers n. Plural of addresser.
ADDRESSER n. one who addresses, also ADDRESSOR.
DEFRAUDERSdefrauders n. Plural of defrauder.
DEFRAUDER n. one who defrauds.
DENDRIMERSdendrimers n. Plural of dendrimer.
DENDRIMER n. a polymer that has a treelike branched molecular structure.
DEODORISERdeodoriser n. Non-Oxford standard spelling of deodorizer.
DEODORISER n. a substance that destroys or conceals unpleasant smells, also DEODORIZER.
DISORDEREDdisordered v. Simple past tense and past participle of disorder.
disordered adj. Chaotic; without clear order; in a state of disorder.
disordered adj. (Of a sequence) in an incorrect or unexpected order.
DRERIHEADSDRERIHEAD n. (Spenser) dreariness, also DREARIHEAD, DREARIHOOD.
DROMEDARESDROMEDARE n. (Spenser) a dromedary, also DROMEDARY.
DRUDGERIESdrudgeries n. Plural of drudgery.
DRUDGERY n. hard, tedious work.
HUNDREDERShundreders n. Plural of hundreder.
HUNDREDER n. an inhabitant or freeholder of a hundred, also HUNDREDOR.
MISORDEREDmisordered v. Simple past tense and past participle of misorder.
MISORDER v. to order incorrectly.
REDSHIRTEDredshirted v. Simple past tense and past participle of redshirt.
REDSHIRT v. to keep a college athlete out of varsity play to extend his eligibility.
RESOLDEREDresoldered v. Simple past tense and past participle of resolder.
RESOLDER v. to solder again.
RUDDERLESSrudderless adj. Without a rudder.
rudderless adj. Lacking guidance or direction.
RUDDERLESS adj. without a rudder.
SHUDDERIERSHUDDERY adj. shuddering.
SLIDDERIERSLIDDERY adj. slippery.
UNDERDOERSunderdoers n. Plural of underdoer.
UNDERDOER n. one who underdoes; a shirker.
UNDERDRESSunderdress v. (Transitive, intransitive) To dress in insufficiently warm clothes.
underdress v. (Transitive, intransitive) To dress in insufficiently formal clothes.
underdress n. (Countable) Any dress#Noun (feminine-style garment) worn under another, especially under an overdress#Noun.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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