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There are 10 ten-letter words containing 2D, 2E, N, O and P

DESPONDENTdespondent adj. In low spirits from loss of hope or courage.
DESPONDENT adj. feeling or showing extreme discouragement.
DISPONDEESdispondees n. Plural of dispondee.
DISPONDEE n. a double spondee; a foot consisting of four long syllables.
ENDOPODITEendopodite n. (Biology) The innermost of two processes attached to the basal process of the limbs of some Crustacea.
ENDOPODITE n. the internal or principal branch of the locomotive appendages of Crustacea.
OPENHANDEDopenhanded adj. Alternative form of open-handed.
openhanded adv. Alternative form of open-handed.
openhanded v. Simple past tense and past participle of openhand.
PERDENDOSIperdendosi n. (Music) A gradual fading away.
PERDENDOSI adv. (Italian) slowing and softening at the same time, also PERDENDO.
PONDERATEDponderated v. Simple past tense and past participle of ponderate.
PONDERATE v. to consider; to ponder.
PROMENADEDpromenaded v. Simple past tense and past participle of promenade.
PROMENADE v. to take a promenade.
UNDEPLOREDundeplored adj. Not deplored.
UNDEPLORED adj. not deplored.
UNEXPLODEDunexploded adj. Not exploded.
UNEXPLODED adj. not exploded.
UNPOWDEREDunpowdered adj. Not powdered.
UNPOWDERED adj. not powdered.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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