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There are 10 ten-letter words containing 2D, 2E, M, S and T

ADDLEMENTSADDLEMENT n. the state of being addled.
DAMNEDESTSDAMNEDEST n. utmost effort, in phrase to do one's damnedest, also DAMNDEST, DAMNEST.
DERMESTIDSdermestids n. Plural of dermestid.
DERMESTID n. any of a family of beetles with clubbed antennae, destructive to organic material.
DESPUMATEDdespumated v. Simple past tense and past participle of despumate.
DESPUMATE v. to throw off impurities in foam or scum.
DESTREAMEDdestreamed v. Simple past tense and past participle of destream.
DESTREAM v. to reverse the categorising of students.
MASTHEADEDmastheaded v. Simple past tense and past participle of masthead.
MASTHEAD v. to raise to the masthead; to punish by sending to the masthead.
MEDIATISEDmediatised v. Simple past tense and past participle of mediatise.
MEDIATISE v. to cause to act through an agent or to hold a subordinate position, also MEDIATIZE.
METHODISEDmethodised v. Simple past tense and past participle of methodise.
METHODISE v. to reduce to method; to arrange in an orderly way; as, to methodize one's work or thoughts, also METHODIZE.
SEDIMENTEDsedimented v. Simple past tense and past participle of sediment.
sedimented adj. (Geology, of a strata) Deposited from sediment.
sedimented adj. (Of a water course) Having much sediment.
STAMPEDOEDstampedoed v. Simple past tense and past participle of stampedo.
STAMPEDO v. (obsolete) to stampede.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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