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There are 20 ten-letter words containing 2D, 3E, N and S

DEADNESSESdeadnesses n. Plural of deadness.
DEADNESS n. the state of being dead.
DECADENCESdecadences n. Plural of decadence.
DECADENCE n. a falling away; decay, also DECADENCY.
DEPENDENTSdependents n. Plural of dependent.
DEPENDENT n. a person who depends on another for support.
DEPREHENDSdeprehends v. Third-person singular simple present indicative form of deprehend.
DEPREHEND v. (obsolete) to catch; to seize.
DESCENDENTdescendent adj. Alternative spelling of descendant.
descendent n. Misspelling of descendant.
DESCENDENT adj. descending; proceeding from an ancestor or source.
DESCENDERSdescenders n. Plural of descender.
DESCENDER n. the part of the lowercase letters, such as g, p, and q, that extends below the other lowercase letters.
DESCENDEURdescendeur n. A piece of metal around which a rope is passed in order to slow descent when abseiling.
DESCENDEUR n. a shaped metal piece through which the rope can be fed, used to control the rate of descent in abseiling.
DUDENESSESDUDENESS n. the state of being a dude.
ENSHIELDEDenshielded v. Simple past tense and past participle of enshield.
ENSHIELD v. to defend, as with a shield.
GENDERISEDgenderised v. Simple past tense and past participle of genderise.
GENDERISE v. to make distinctions according to gender, also GENDERIZE.
LEGENDISEDlegendised v. Simple past tense and past participle of legendise.
LEGENDISE v. to make into a legend, also LEGENDIZE.
REASCENDEDreascended v. Simple past tense and past participle of reascend.
REASCEND v. to ascend again.
REDESCENDSredescends v. Third-person singular simple present indicative form of redescend.
REDESCEND v. to descend again.
REDESIGNEDredesigned v. Simple past tense and past participle of redesign.
REDESIGN v. to design again.
RESPLENDEDresplended v. Simple past tense and past participle of resplend.
RESPLEND v. to shine brilliantly.
SEDIMENTEDsedimented v. Simple past tense and past participle of sediment.
sedimented adj. (Geology, of a strata) Deposited from sediment.
sedimented adj. (Of a water course) Having much sediment.
TENDERISEDtenderised v. Simple past tense and past participle of tenderise.
TENDERISE v. to make tender, also TENDERIZE.
UNDERFEEDSunderfeeds v. Third-person singular simple present indicative form of underfeed.
UNDERFEED v. to feed inadequately.
UNDERSEXEDundersexed adj. Lacking sufficient sexual desire or activity; sexually unfulfilled; sexually frustrated.
UNDERSEXED adj. deficient in sexual desire.
UNDESERVEDundeserved adj. Not deserved, earned or merited; unjustifiable or unfair.
UNDESERVE v. to fail to deserve.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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