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There are 6 eight-letter words containing D, 2E, M and 2O

DOLESOMEdolesome adj. Doleful; dismal; gloomy.
DOLESOME adj. doleful, dismal.
ENDOSOMEendosome n. (Biology) An endocytic vacuole through which molecules internalized during endocytosis pass en route to lysosomes.
ENDOSOME n. a cellular particle.
MELODEONmelodeon n. (Historical, music) A type of reed organ with a single keyboard.
melodeon n. (Music) An accordion where the melody-side keyboard is limited to the notes of diatonic scales in a…
melodeon n. (Historical, US) A music hall.
MOONSEEDmoonseed n. A twining plant of the genera Menispermum or Cocculus, in the family Menispermaceae.
MOONSEED n. a plant of genus Menispermum with lunate seeds.
ODOMETERodometer n. An instrument, usually embedded within the speedometer of a vehicle, that measures the distance the…
odometer n. A wheel used by surveyors, which registers distance traveled.
ODOMETER n. a device for measuring distance travelled, also ODOGRAPH.
PODOMEREpodomere n. A segment of a limb of an arthropod.
PODOMERE n. a limb segment of an arthropod, also PODITE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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