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There are 8 eight-letter words containing 2D, 2I, S and U

DISODIUMdisodium n. (Chemistry, in combination) two atoms of sodium in a compound.
DISODIUM adj. of a molecule, having two sodium atoms.
DISULFIDdisulfid n. Archaic form of disulphide.
DISULFID n. a sulphide containing two atoms of sulphur to the molecule, also DISULFIDE, DISULPHIDE, DISULPHURET.
DRUIDISMdruidism n. The religion, philosophical beliefs, and attendant ritual practices of the druids.
Druidism n. The religion and philosophical beliefs promoting harmony with nature, and drawing on the practices of the druids.
DRUIDISM n. the religious system of the druids.
FIDDIOUSFIDDIOUS v. (Shakespeare) to treat as leniently as Coriolanus treated Aufidius.
QUIDDITSquiddits n. Plural of quiddit.
QUIDDIT n. (archaic) the inherent nature or essence of anything; any trifling nicety; a quibble, also QUIDDITY.
RUDISTIDRUDISTID n. a cone-shaped extinct mollusc, also RUDIST.
SIDDURIMsiddurim n. Plural of siddur.
SIDDUR n. (Hebrew) a Jewish prayer book containing prayers and other information relevant to the daily liturgy.
SUICIDEDsuicided v. Simple past tense and past participle of suicide.
suicided adj. Having killed oneself or self-destructed.
SUICIDE v. to kill oneself intentionally.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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