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There are 16 seven-letter words containing 2D, 2E, N and S

DEADENSdeadens v. Third-person singular simple present indicative form of deaden.
DEADEN v. to deprive of feeling.
DEFENDSdefends v. Third-person singular simple present indicative form of defend.
DEFEND v. to protect.
DENUDESdenudes v. Third-person singular simple present indicative form of denude.
DENUDE v. to strip of all covering, also DENUDATE.
DEPENDSdepends v. Third-person singular simple present indicative form of depend.
DEPEND v. to rely.
DESCENDdescend v. (Intransitive) To pass from a higher to a lower place; to move downwards; to come or go down in any…
descend v. (Intransitive, poetic) To enter mentally; to retire.
descend v. (Intransitive, with on or upon) To make an attack, or incursion, as if from a vantage ground; to come…
DESINEDDESINE v. (Spenser) to plan in outline, also DESIGN, DESYNE.
DESYNEDdesyned v. Simple past tense and past participle of desyne.
DESYNE v. (Spenser) to plan in outline, also DESIGN, DESINE.
DUDEENSdudeens n. Plural of dudeen.
DUDEEN n. (Irish) a clay pipe, also DUDHEEN.
DUENDESduendes n. Plural of duende.
DUENDE n. (Spanish) the power to attract through personal charm.
LEDDENSLEDDEN n. (Spenser) language, dialect, speech.
NEDDIESneddies n. Plural of neddy.
NEDDY n. a pet name for a donkey.
REDDENSreddens v. Third-person singular simple present indicative form of redden.
REDDEN v. to make or become red.
SCENDEDscended v. Simple past tense and past participle of scend.
SCEND v. of a ship, to pitch into the trough of the sea, also SEND.
SDEINEDsdeined v. Simple past tense and past participle of sdein.
SDEIN v. (obsolete) to disdain, also SDAINE, SDAYN, SDEIGN, SDEIGNE.
SNEDDEDsnedded v. Simple past tense and past participle of sned.
SNED v. to cut, lop.
STENDEDSTEND v. (Scots) to bound, stride vigorously, also STEN.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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