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There are 13 fifteen-letter words containing D, 2E, 2F and R

DEDIFFERENTIATEdedifferentiate v. To lose or reverse differentiation.
DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DEXFENFLURAMINEdexfenfluramine n. A serotonergic anorectic drug used for weight loss in the 1990s, later withdrawn because of cardiovascular…
DIFFERENTIATINGdifferentiating v. Present participle of differentiate.
DIFFERENTIATE v. to obtain the mathematical derivative of.
DIFFERENTIATIONdifferentiation n. The act or process of differentiating (generally, without a specialized sense).
differentiation n. (Biology) The process by which the components of multicellular life (Cells, organs, etc.) are produced…
differentiation n. (Biology, evolution) The evolutionary process by which one taxonomic group (Species, genus, variety…
DIFFERENTIATORSdifferentiators n. Plural of differentiator.
DIFFERENTIATOR n. someone who or that which differentiates.
DIFFERENTNESSESdifferentnesses n. Plural of differentness.
DIFFERENTNESS n. DIFFERENT, separate, unlike.
DIFFRACTIVENESSDIFFRACTIVE n. causing diffraction.
DIFFRACTOMETERSdiffractometers n. Plural of diffractometer.
DIFFRACTOMETER n. an instrument for determining structure of crystal through light diffraction.
DISAFFORESTMENTdisafforestment n. Disafforestation.
DISAFFORESTMENT n. the act of disafforesting.
FURFURALDEHYDESFURFURALDEHYDE n. a liquid obtained by heating bran with dilute sulphuric acid, also FURAL, FURFURAL, FURFUROL, FURFUROLE, FUROL, FUROLE.
INDIFFERENTISMSindifferentisms n. Plural of indifferentism.
INDIFFERENTISM n. the belief that all religions are equally valid.
INDIFFERENTISTSindifferentists n. Plural of indifferentist.
INDIFFERENTIST n. an exponent of indifferentism.
UNRUFFLEDNESSESUNRUFFLEDNESS n. the state of being unruffled.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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