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There are 10 fifteen-letter words containing 2D, R, 2S and U

DEINDUSTRIALISEdeindustrialise v. Alternative spelling of deindustrialize.
DEINDUSTRIALISE v. to disperse or reduce the industrial organization and potential of a nation, area, etc., also DEINDUSTRIALIZE.
DESPIRITUALISEDDESPIRITUALISE v. to deprive of spiritual character or influence, also DESPIRITUALIZE.
INDIVIDUALISERSindividualisers n. Plural of individualiser.
INDIVIDUALISER n. one who individualises, also INDIVIDUALIZER.
OXIDOREDUCTASESoxidoreductases n. Plural of oxidoreductase.
OXIDOREDUCTASE n. an enzyme that catalyzes an oxidationreduction reaction.
ROUNDHEADEDNESSROUNDHEADEDNESS n. the state of being roundheaded.
UNBRIDLEDNESSESUNBRIDLEDNESS n. the state of being unbridled.
UNDEREMPHASISEDunderemphasised adj. Alternative spelling of underemphasized.
UNDEREMPHASISE v. to emphasise insufficiently, also UNDEREMPHASIZE.
UNDERHANDEDNESSunderhandedness n. The characteristic of being underhanded.
under-handedness n. Alternative form of underhandedness.
UNDERHANDEDNESS n. the state of being underhanded.
UNDERSUBSCRIBEDundersubscribed adj. Having too few subscribers or subscriptions.
undersubscribed v. Simple past tense and past participle of undersubscribe.
UNDERSUBSCRIBED adj. insufficiently subscribed.
UNGUARDEDNESSESunguardednesses n. Plural of unguardedness.
UNGUARDEDNESS n. the state of being unguarded.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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