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There are 13 fifteen-letter words containing 2D, 2I, M and S

ADENOIDECTOMIESadenoidectomies n. Plural of adenoidectomy.
ADENOIDECTOMY n. the surgical removal of the adenoids, also ADENECTOMY.
AMPHIDIPLOIDIESAMPHIDIPLOIDY n. the state of being amphidiploid.
AUTODIDACTICISMautodidacticism n. Self-education; self-directed learning.
AUTODIDACTICISM n. the state of being autodidactic.
AZIDOTHYMIDINESazidothymidines n. Plural of azidothymidine.
AZIDOTHYMIDINE n. a derivative of thymidine.
DIMENHYDRINATESdimenhydrinates n. Plural of dimenhydrinate.
DIMENHYDRINATE n. a crystalline antihistamine used esp. to prevent nausea, as in motion sickness.
DISCOMMENDATIONdiscommendation n. (Archaic) blame; censure; reproach; shunning.
DISCOMMENDATION n. the act of discommending.
DISCOMMISSIONEDdiscommissioned v. Simple past tense and past participle of discommission.
DISCOMMISSION v. (Milton) to deprive of a commission.
DISCOMMODIOUSLYdiscommodiously adv. In a discommodious manner.
DISCOMMODIOUS adv. inconvenient.
DISINTERMEDIATEdisintermediate v. (Business, banking, finance) To carry out disintermediation.
HYDRODYNAMICISThydrodynamicist n. One who studies hydrodynamics.
HYDRODYNAMICIST n. a student of hydrodynamics.
MALADMINISTEREDmaladministered v. Simple past tense and past participle of maladminister.
MALADMINISTER v. to administer wrongly.
MISGUIDEDNESSESmisguidednesses n. Plural of misguidedness.
MISGUIDEDNESS n. the state of being misguided.
MULTICANDIDATESSorry, definition not available.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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