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There are 8 fifteen-letter words containing 2D, E, M and 2N

ANDROMEDOTOXINSandromedotoxins n. Plural of andromedotoxin.
ANDROMEDOTOXIN n. a poisonous substance extracted from plants of the heath family and used in medicine to lower high blood pressure.
DEMANDINGNESSESDEMANDINGNESS n. the state of being demanding.
DIMENHYDRINATESdimenhydrinates n. Plural of dimenhydrinate.
DIMENHYDRINATE n. a crystalline antihistamine used esp. to prevent nausea, as in motion sickness.
DIPHENHYDRAMINEdiphenhydramine n. (Pharmacology) An antihistamine and anticholinergic drug that blocks the effect of histamine at H1 receptor…
DIPHENHYDRAMINE n. a type of antihistamine.
DISCOMMENDATIONdiscommendation n. (Archaic) blame; censure; reproach; shunning.
DISCOMMENDATION n. the act of discommending.
MADDENINGNESSESMADDENINGNESS n. the state of being maddening.
MIDDELMANNETJIEmiddelmannetjie n. (South Africa) A ridge between ruts made by wheels in a dirt or gravel road.
MIDDELMANNETJIE n. (South African) a ridge between the ruts made by wheels in a dirt road.
UNDEMANDINGNESSundemandingness n. The quality of being undemanding; lack of difficulty or challenge.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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