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There are 7 twelve-letter words containing 2D, 2I and 2R

DIARTHRODIALdiarthrodial adj. (Anatomy) Relating to diarthrosis, or movable articulations.
DIARTHRODIAL adj. of or like a diarthrosis, a joint permitting free movement.
DISORDERLIESdisorderlies n. Plural of disorderly.
DISORDERLY n. a disorderly person.
DISREGARDINGdisregarding v. Present participle of disregard.
DISREGARD v. to pay no attention to.
LIRIODENDRONliriodendron n. Any of several large North American trees, of the genus Liriodendron, that have tulip-like flowers;…
Liriodendron prop.n. A taxonomic genus within the family Magnoliaceae – the two species of tulip tree.
LIRIODENDRON n. the tulip tree.
REDISTRICTEDredistricted v. Simple past tense and past participle of redistrict.
REDISTRICT v. to divide into new districts.
UNDERGIRDINGundergirding v. Present participle of undergird.
UNDERGIRD v. to form the basis or foundation of, to support from below.
UNIRRADIATEDunirradiated adj. Not irradiated.
UNIRRADIATED adj. not irradiated.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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