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There are 12 twelve-letter words containing 2D, 2G, I and R

BIODEGRADINGbiodegrading v. Present participle of biodegrade.
BIODEGRADE v. to break down by biological action.
BIRDDOGGINGSBIRDDOGGING n. the act of controlling closely with unceasing vigilance.
BODYGUARDINGbodyguarding n. The profession of a bodyguard, protecting another from harm.
BODYGUARD v. to act as a bodyguard.
DEGRINGOLADEdegringolade n. A rapid decline or deterioration; a tumble.
dégringolade n. Alternative spelling of degringolade.
DEGRINGOLADE v. (French) to make a rapid descent.
DIGITIGRADESdigitigrades n. Plural of digitigrade.
DIGITIGRADE n. an animal that walks on the toes alone.
DISREGARDINGdisregarding v. Present participle of disregard.
DISREGARD v. to pay no attention to.
DITCHDIGGERSditchdiggers n. Plural of ditchdigger.
DITCHDIGGER n. one that digs ditches.
DRAGONNADINGDRAGONNADE v. to persecute by troops.
SLUGGARDISEDsluggardised v. Simple past tense and past participle of sluggardise.
SLUGGARDISE v. (Shakespeare) to make lazy, also SLUGGARDIZE.
SLUGGARDIZEDsluggardized v. Simple past tense and past participle of sluggardize.
SLUGGARDIZE v. (Shakespeare) to make lazy, also SLUGGARDISE.
STRIDELEGGEDstridelegged v. Simple past tense and past participle of strideleg.
stridelegged adj. In a position astride something.
STRIDELEGGED adv. (Scots) astride, also STRIDELEGS.
UNDERGIRDINGundergirding v. Present participle of undergird.
UNDERGIRD v. to form the basis or foundation of, to support from below.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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