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There are 12 twelve-letter words containing 2D, 2E, F and M

BEFUDDLEMENTbefuddlement n. The state of being befuddled.
BEFUDDLEMENT n. the state of being befuddled.
DEFORMALISEDDEFORMALISE v. to make less formal, also DEFORMALIZE.
DEFORMALIZEDdeformalized v. Simple past tense and past participle of deformalize.
DEFORMALIZE v. to make less formal, also DEFORMALISE.
DEFORMEDNESSdeformedness n. (Obsolete, rare) The quality or state of being deformed.
DEFORMEDNESS n. the state of being deformed.
DEFRAGMENTEDdefragmented v. Simple past tense and past participle of defragment.
DEFRAGMENT v. to run a program which reduces or eliminates the fragmentation of (a file or disk) by bringing together parts of files stored in separate locations to a single location on the disk.
DEFRAUDMENTSdefraudments n. Plural of defraudment.
DEFRAUDMENT n. the act of defrauding.
DEHUMIDIFIEDdehumidified v. Simple past tense and past participle of dehumidify.
DEHUMIDIFY v. to remove moisture from (as air).
DEHUMIDIFIERdehumidifier n. A device for removing the moisture content from air.
DEHUMIDIFIER n. an apparatus for reducing humidity.
DEHUMIDIFIESdehumidifies v. Third-person singular simple present indicative form of dehumidify.
DEHUMIDIFY v. to remove moisture from (as air).
DUMFOUNDEREDdumfoundered v. Simple past tense and past participle of dumfounder.
DUMFOUNDER v. to strike dumb; to confuse with astonishment, also DUMBFOUND, DUMBFOUNDER, DUMFOUND.
FEEBLEMINDEDfeebleminded adj. Alternative spelling of feeble-minded.
feeble-minded adj. Weak in intellectual power; lacking firmness or constancy; lacking intelligence.
FEEBLEMINDED adj. mentally deficient.
FORMALDEHYDEformaldehyde n. (Organic chemistry) The simplest aldehyde, HCHO, a colourless gas that has many industrial applications;…
FORMALDEHYDE n. a formic aldehyde, formalin.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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