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There are 8 eight-letter words containing 2D, F, N and R

DANDRIFFdandriff n. Archaic spelling of dandruff.
DANDRIFF n. a scurf that forms on the scalp, also DANDRUFF.
DANDRUFFdandruff n. Scaly white dead skin flakes from the human scalp; Pityriasis capitis.
dandruff v. To fall or cover with white flakes, like dandruff.
DANDRUFF n. a scurf that forms on the scalp, also DANDRIFF.
DEFENDERdefender n. Someone who defends people or property.
defender n. (Sports) One of the players whose primary task is to prevent the opposition from scoring.
defender n. A fighter who seeks to repel an attack.
DEFRIENDdefriend v. (Social media, uncommon) To remove from one’s list of friends (e.g. on a social networking website).
DEFRIEND v. to remove someone from one's list of friends on a social networking site.
FENDEREDfendered adj. Having a specified kind or number of fenders.
FENDERED adj. having a fender.
FRIENDEDfriended v. Simple past tense and past participle of friend.
friended adj. Supplied with friends.
FRIEND v. to enter into a warm association with.
REFUNDEDrefunded v. Simple past tense and past participle of refund.
REFUND v. to give back.
UNDERFEDunderfed adj. Inadequately fed.
underfed v. Simple past tense and past participle of underfeed.
UNDERFED adj. fed an insufficient amount.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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