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There are 16 words containing 2C, E, 2F and U

EFFICACIOUSefficacious adj. (Formal) Effective; possessing efficacy.
EFFICACIOUS adj. having the power to produce a desired effect.
EFFICACIOUSLYefficaciously adv. In an efficacious manner.
EFFICACIOUS adv. having the power to produce a desired effect.
EFFICACIOUSNESSefficaciousness n. Quality of being efficacious.
EFFICACIOUS n. having the power to produce a desired effect.
FUCKFACEfuckface n. (Vulgar, derogatory) An ugly or otherwise undesirable or annoying person.
fuck-face n. Alternative spelling of fuckface.
fuck␣face n. (Vulgar, slang) A person’s facial expression during orgasm.
FUCKFACESfuckfaces n. Plural of fuckface.
fuck␣faces n. Plural of fuck face.
FUCKFACE n. a contemptibly stupid person.
INEFFICACIOUSinefficacious adj. Incapable of having the intended consequence.
inefficacious adj. Not effective.
INEFFICACIOUS adj. lacking the power to produce a desired effect.
INEFFICACIOUSLYinefficaciously adv. Without efficacy or effect.
INEFFICACIOUS adv. lacking the power to produce a desired effect.
INSUFFICIENCEinsufficience n. Obsolete form of insufficiency.
INSUFFICIENCE n. the state of being insufficient, also INSUFFICIENCY.
INSUFFICIENCESINSUFFICIENCE n. the state of being insufficient, also INSUFFICIENCY.
INSUFFICIENCIESinsufficiencies n. Plural of insufficiency.
INSUFFICIENCY n. the state of being insufficient, also INSUFFICIENCE.
INSUFFICIENCYinsufficiency n. The lack of sufficiency; a shortage or inadequacy.
INSUFFICIENCY n. the state of being insufficient, also INSUFFICIENCE.
SUFFICIENCEsufficience n. (Obsolete) The condition or quality of being sufficient; sufficiency.
sufficience n. (Obsolete) Capability; competence.
SUFFICIENCE n. (archaic) a sufficiency.
SUFFICIENCESsufficiences n. Plural of sufficience.
SUFFICIENCE n. (archaic) a sufficiency.
SUFFICIENCIESsufficiencies n. Plural of sufficiency.
SUFFICIENCY n. the state of being sufficient, also SUFFICIENCE.
SUFFICIENCYsufficiency n. (Uncountable) The quality or condition of being sufficient.
sufficiency n. (Countable) An adequate amount.
SUFFICIENCY n. the state of being sufficient, also SUFFICIENCE.
SUPEREFFICIENCYsuperefficiency n. The quality of being superefficient.
SUPEREFFICIENCY n. the state of being superefficient.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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