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There are 15 twelve-letter words containing 2C, M, 2S and U

ASCOMYCETOUSascomycetous adj. (Mycology) Of or relating to the ascomycetes.
ASCOMYCETOUS adj. relating to ascomycete.
CIRCUMCISERScircumcisers n. Plural of circumciser.
CIRCUMCISER n. one who circumcises.
COSMONAUTICScosmonautics n. The activities of cosmonauts; Soviet/Russian astronautics.
COSMONAUTICS n. Russian astronautics.
CYCLOSTOMOUScyclostomous adj. (Zoology) Relating to the cyclostomes.
CYCLOSTOMOUS adj. of or like a cyclostome.
DISACCUSTOMSdisaccustoms v. Third-person singular simple present indicative form of disaccustom.
DISACCUSTOM v. to free from a habit.
ECUMENICISMSecumenicisms n. Plural of ecumenicism.
ECUMENICISM n. the doctrines and practice of the Christian ecumenical movement, also ECUMENICALISM.
ECUMENICISTSecumenicists n. Plural of ecumenicist.
ECUMENICIST n. a believer in ecumenicism.
ESCARMOUCHESescarmouches n. Plural of escarmouche.
ESCARMOUCHE n. (obsolete) a skirmish.
MISCONSTRUCTmisconstruct v. To construct wrongly.
misconstruct v. To construe or interpret erroneously.
MISCONSTRUCT v. to construct wrongly.
MISCREAUNCESMISCREAUNCE n. (Spenser) false religious belief, also MISCREANCE, MISCREANCY.
SCARAMOUCHESSCARAMOUCH v. to behave like a rascal or cowardly fool.
SMILACACEOUSsmilacaceous adj. (Botany) Belonging to the Smilacaceae.
SMILACACEOUS adj. belonging to the smilax family.
SPUMESCENCESSPUMESCENCE n. foaminess, frothiness.
SUCCEDANEUMSsuccedaneums n. Plural of succedaneum.
SUCCEDANEUM n. (Latin) a substitute; a remedy.
TECHNOMUSICSTECHNOMUSIC n. a type of fast, repetitive electronic dance music.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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