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There are 12 twelve-letter words containing B, 2I, 2S and 2U

BIUNIQUENESSbiuniqueness n. The quality of being biunique.
BIUNIQUENESS n. the state of being biunique.
INSALUBRIOUSinsalubrious adj. Unhealthful, not providing or promoting health.
INSALUBRIOUS adj. unhealthy, deleterious.
SUBAUDITIONSsubauditions n. Plural of subaudition.
SUBAUDITION n. understanding of something not expressed.
SUBDELIRIOUSSUBDELIRIOUS adj. mildly or intermittently delirious.
SUBDELIRIUMSSUBDELIRIUM n. a mild or intermittent delirium.
SUBMUNITIONSsubmunitions n. Plural of submunition.
SUBMUNITION n. any of a group of smaller weapons carried as a warhead by a missile or projectile and expelled as the carrier approaches its target.
SUBSTITUTINGsubstituting v. Present participle of substitute.
SUBSTITUTE v. to put or use in the place of another.
SUBSTITUTIONsubstitution n. The act of substituting or the state of being substituted.
substitution n. A substitute or replacement.
substitution n. (Chemistry, especially organic chemistry) The replacement of an atom, or group of atoms, in a compound, with another.
SUBSTITUTIVEsubstitutive adj. Characteristic of, or serving as a substitute.
SUBSTITUTIVE adj. serving or suitable as a substitute.
UNSUBMISSIVEunsubmissive adj. Unwilling to submit; not submissive, disobedient.
UNSUBMISSIVE adj. not submissive.
UNSUBSIDISEDunsubsidised adj. Alternative spelling of unsubsidized.
UNSUBSIDISED adj. not subsidised, also UNSUBSIDIZED.
UNSUBSIDIZEDunsubsidized adj. Not subsidized.
UNSUBSIDIZED adj. not subsidized, also UNSUBSIDISED.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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