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There are 6 twelve-letter words containing B, R, S and 3U

LUGUBRIOUSLYlugubriously adv. In a lugubrious manner.
LUGUBRIOUS adv. mournful, dismal, esp. in an exaggerated or affected manner.
RUMBUNCTIOUSrumbunctious adj. Alternative spelling of rambunctious.
RUMBUNCTIOUS adj. boisterous, unruly, also RAMBUNCTIOUS.
SUBAURICULARsubauricular adj. Beneath the ear.
SUBAURICULAR adj. below the ear.
SUBCULTURINGsubculturing v. Present participle of subculture.
subculturing n. The preparation of a subculture.
SUBCULTURE v. to create a subculture e.g. of bacteria.
SUBOPERCULUMsuboperculum n. (Anatomy) The lower opercular bone in fishes.
SUBOPERCULUM n. in fishes, a bone below and partly behind the gill cover.
SUBSTRUCTUREsubstructure n. The supporting part of a structure (either physical or organizational; the foundation).
substructure n. The earth or gravel that the railway tracks are embedded in.
substructure n. (Marxism) Synonym of base (“the forces and relations of production that produce the necessities and…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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