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There are 20 fifteen-letter words containing A, E, 2I, 3R and S

ANTIRETROVIRALSantiretrovirals n. Plural of antiretroviral.
ANTIRETROVIRAL n. any retroviral drug used to treat diseases caused by retroviruses, such as HIV.
ARBITRARINESSESarbitrarinesses n. Plural of arbitrariness.
ARBITRARINESS n. the state of being arbitrary.
ARTERIOGRAPHIESarteriographies n. Plural of arteriography.
ARTERIOGRAPHY n. the radiographic visualization of an artery after injection of a radiopaque substance.
EXTRAORDINARIESextraordinaries n. Plural of extraordinary.
extra-ordinaries n. Plural of extra-ordinary.
EXTRAORDINARY n. something out of the ordinary.
HERNIORRHAPHIESherniorrhaphies n. Plural of herniorrhaphy.
HERNIORRHAPHY n. the surgical repair of a hernia by an operation involving suturing.
HISTORIOGRAPHERhistoriographer n. A scholar who studies historiography.
HISTORIOGRAPHER n. one who practises historiography, the study of writing history.
INSURRECTIONARYinsurrectionary adj. Pertaining to, or characterized by, insurrection.
insurrectionary n. One who takes part in insurrection.
INSURRECTIONARY adj. relating to insurrection.
INTERROGATORIESinterrogatories n. Plural of interrogatory.
INTERROGATORY n. a question or interrogation.
MARGARITIFEROUSmargaritiferous adj. Producing pearls.
MARGARITIFEROUS adj. pearl-bearing.
PARTICULARISERSPARTICULARISER n. one who particularises, also PARTICULARIZER.
PARTICULARIZERSparticularizers n. Plural of particularizer.
PARTICULARIZER n. one who particularizes, also PARTICULARISER.
PREREGISTRATIONpreregistration n. An early registration, before the normal or traditional time, as with early online check-in at hotels.
preregistration n. Registration (of a study design) before a clinical trial (or any other type of scientific experiment)…
preregistration adj. Before registration.
REFRIGERATORIESrefrigeratories n. Plural of refrigeratory.
REFRIGERATORY n. a refrigerator; a chamber in which ice is formed.
REREGISTRATIONSreregistrations n. Plural of reregistration.
REREGISTRATION n. the act of reregistering.
SEMITERRESTRIALsemiterrestrial adj. (Of an animal) partly terrestrial, living sometimes on land.
SEMITERRESTRIAL adj. growing on boggy ground.
TERRITORIALISEDterritorialised v. Simple past tense and past participle of territorialise.
TERRITORIALISE v. to organize on a territorial basis, also TERRITORIALIZE.
TERRITORIALISESterritorialises v. Third-person singular simple present indicative form of territorialise.
TERRITORIALISE v. to organize on a territorial basis, also TERRITORIALIZE.
TERRITORIALISMSterritorialisms n. Plural of territorialism.
TERRITORIALISM n. a social system in which the landowning class is dominant, organized on a territorial basis.
TERRITORIALISTSterritorialists n. Plural of territorialist.
TERRITORIALIST n. a supporter of territorialism.
TERRITORIALIZESterritorializes v. Third-person singular simple present indicative form of territorialize.
TERRITORIALIZE v. to organize on a territorial basis, also TERRITORIALISE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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