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There are 16 twelve-letter words containing A, C, E, F, 3I and S

DEIFICATIONSdeifications n. Plural of deification.
DEIFICATION n. the act or an instance of deifying.
EDIFICATIONSedifications n. Plural of edification.
EDIFICATION n. an act of edifying.
EFFICACITIESefficacities n. Plural of efficacity.
EFFICACITY n. the state of being efficacious.
FACSIMILEINGfacsimileing v. Present participle of facsimile.
FACSIMILE v. to make a facsimile of.
FAIRNITICLESFAIRNITICLE n. (Scots) a freckle, also FAIRNITICKLE, FAIRNYTICKLE, FAIRNYTICLE, FERNITICKLE, FERNITICLE, FERNTICKLE, FERNTICLE, FERNYTICKLE, FERNYTICLE.
FICTIONALISEfictionalise v. Non-Oxford British spelling standard spelling of fictionalize.
FICTIONALISE v. to make fictional, also FICTIONALIZE.
FINICALITIESfinicalities n. Plural of finicality.
FINICALITY n. the quality of being finical.
FLACCIDITIESflaccidities n. Plural of flaccidity.
FLACCIDITY n. the state of being flaccid.
INEFFICACIESinefficacies n. Plural of inefficacy.
INEFFICACY n. lack of power to produce a desired effect, also INEFFICACITY.
INFANTICIDESinfanticides n. Plural of infanticide.
INFANTICIDE n. the killing of a small child.
OFFICIALTIESofficialties n. Plural of officialty.
OFFICIALTY n. the charge, office, court, or jurisdiction of an official, also OFFICIALITY.
REIFICATIONSreifications n. Plural of reification.
REIFICATION n. the process or result of reifying.
SCIENTIFICALscientifical adj. Of or pertaining to the scientific method.
SCIENTIFICAL adj. of, relating to, or exhibiting the methods or principles of science, also SCIENTIFIC.
SEMIOFFICIALsemiofficial adj. Alternative spelling of semi-official.
semi-official adj. Having some degree of official authority.
SEMIOFFICIAL adj. having some official authority or standing.
SIGNIFICANCEsignificance n. The extent to which something matters; importance.
significance n. Meaning.
SIGNIFICANCE n. something that is conveyed as a meaning often obscurely or indirectly.
SIGNIFICATESsignificates n. Plural of significate.
SIGNIFICATE n. a thing signified.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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