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There are 17 words containing 2A, D, 3E, P and S

ADAPTABLENESSESADAPTABLENESS n. the state of being adaptable.
ADAPTEDNESSESadaptednesses n. Plural of adaptedness.
ADAPTEDNESS n. the state of being adapted.
ADAPTIVENESSESadaptivenesses n. Plural of adaptiveness.
ADAPTIVENESS n. the quality of being adaptive.
DEPARTMENTALISEdepartmentalise v. Alternative spelling of departmentalize.
DEPARTMENTALISE v. to form into separate departments, also DEPARTMENTALIZE.
DEPAUPERATESdepauperates v. Third-person singular simple present indicative form of depauperate.
DEPAUPERATE v. to impoverish.
DEXAMPHETAMINESDEXAMPHETAMINE n. the dextrorotatory isomer of amphetamine, used as a stimulant.
DISPARATENESSESdisparatenesses n. Plural of disparateness.
DISPARATENESS n. DISPARATE, unequal, essentially unlike.
EXASPERATEDexasperated v. Simple past tense and past participle of exasperate.
exasperated adj. Having one’s patience greatly taxed; greatly annoyed; made furious.
exasperated adj. Made worse or more intense.
EXASPERATEDLYexasperatedly adv. In an exasperated manner.
EXASPERATED adv. EXASPERATE, to excite the anger of.
HEADPEACESheadpeaces n. Plural of headpeace.
HEADPEACE n. (archaic) a helmet, also HEADPIECE.
PAEDERASTIESPAEDERASTY n. anal intercourse between a man and a boy, also PEDERASTY.
PARALLELEPIPEDSparallelepipeds n. Plural of parallelepiped.
PARALLELEPIPED n. a solid figure with each face a parallelogram.
PARAMETERISEDparameterised v. Simple past tense and past participle of parameterise.
PARAMETERISE v. to set parameters for, also PARAMETERIZE.
PSEUDAESTHESIApseudaesthesia n. (Medicine) phantom pain, false or imaginary feeling or sense perception such as occurs in hypochondriasis…
pseudæsthesia n. Rare spelling of pseudaesthesia.
PSEUDAESTHESIA n. imaginary feeling or sensation.
PSEUDAESTHESIASPSEUDAESTHESIA n. imaginary feeling or sensation.
SPEARHEADEDspearheaded v. Simple past tense and past participle of spearhead.
SPEARHEAD v. to lead an attack.
SPREADEAGLEDspreadeagled v. Simple past tense and past participle of spreadeagle.
spread-eagled v. Simple past tense and past participle of spread-eagle.
spread-eagled adj. In a spread eagle position.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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