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There are 12 fifteen-letter words containing 2A, C, 3E, I and S

ACCESSARINESSESACCESSARINESS n. the state of being accessary.
ADRENALECTOMIESadrenalectomies n. Plural of adrenalectomy.
ADRENALECTOMY n. the surgical removal of the adrenal glands.
CARPETBAGGERIESCARPETBAGGERY n. the actions of a carpetbagger.
CAUSATIVENESSESCAUSATIVENESS n. CAUSATIVE, relating to causation.
EVANGELICALNESSevangelicalness n. The quality of being evangelical.
EVANGELICALNESS n. the state of being evangelical.
INCAPABLENESSESINCAPABLENESS n. the state of being incapable.
MACRENCEPHALIESMACRENCEPHALY n. the condition of having an abnormally large brain, also MACRENCEPHALIA, MACROCEPHALIA.
MEGALOCEPHALIESMEGALOCEPHALY n. the condition of having an unusually large head or cranial capacity, also MEGACEPHALY.
MESATICEPHALIESMESATICEPHALY n. the state of being mesaticephalic.
PALAEOECOLOGIESpalaeoecologies n. Plural of palaeoecology.
PALAEOECOLOGY n. the study of early ecology.
PREANAESTHETICSpreanaesthetics n. Plural of preanaesthetic.
PREANAESTHETIC n. a drug administered prior to an anaesthetic, also PREANESTHETIC.
REACCELERATIONSreaccelerations n. Plural of reacceleration.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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