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There are 18 twelve-letter words containing 2A, E, F, I, N, R and S

ACRIFLAVINESacriflavines n. Plural of acriflavine.
ACRIFLAVINE n. an antiseptic, also ACRIFLAVIN.
AFFRANCHISEDaffranchised v. Simple past tense and past participle of affranchise.
AFFRANCHISE v. to free from slavery or similar obligation.
AFFRANCHISESaffranchises v. Third-person singular simple present indicative form of affranchise.
AFFRANCHISE v. to free from slavery or similar obligation.
AIRCRAFTSMENaircraftsmen n. Plural of aircraftsman.
AIRCRAFTSMAN n. a member of the lowest (male) rank in the RAF, also AIRCRAFTMAN.
BREAKFASTINGbreakfasting v. Present participle of breakfast.
breakfasting n. The act of eating breakfast.
BREAKFAST v. to take breakfast.
FACTIONARIESfactionaries n. Plural of factionary.
FACTIONARY n. a member of a faction.
FAMILIARNESSfamiliarness n. Quality of being familiar.
FAMILIARNESS n. the state of being familiar.
FARCICALNESSfarcicalness n. The property of being farcical.
FARCICALNESS n. the state of being farcical.
FARTHINGALESfarthingales n. Plural of farthingale.
FARTHINGALE n. a skirt spreader.
FLEXITARIANSflexitarians n. Plural of flexitarian.
FLEXITARIAN n. a vegetarian who is less than strict about what he or she eats.
FRACTIONATESfractionates v. Third-person singular simple present indicative form of fractionate.
FRACTIONATE v. to separate a mixture into different portions esp. by a fractional process.
FRATERNALISMfraternalism n. Fraternal policies or practices; brotherliness.
FRATERNALISM n. being fraternal.
INFRACLASSESinfraclasses n. Plural of infraclass.
PARAFFINIESTPARAFFINY adj. of or like paraffin.
RAREFACTIONSrarefactions n. Plural of rarefaction.
RAREFACTION n. the act of rarefying.
SAFECRACKINGsafecracking n. The act of defeating the security mechanisms of a safe or vault to gain access to its contents.
SAFECRACKING n. the act of breaking open a safe.
SAFEGUARDINGsafeguarding v. Present participle of safeguard.
safeguarding n. Synonym of protection.
safeguarding n. (UK, Ireland, formal) Policies and actions for the protection of children and vulnerable adults.
SPACEFARINGSSPACEFARING n. voyaging in space.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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