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There are 20 twelve-letter words containing 2A, C, E, F, I, R and S

ACRIFLAVINESacriflavines n. Plural of acriflavine.
ACRIFLAVINE n. an antiseptic, also ACRIFLAVIN.
AFFRANCHISEDaffranchised v. Simple past tense and past participle of affranchise.
AFFRANCHISE v. to free from slavery or similar obligation.
AFFRANCHISESaffranchises v. Third-person singular simple present indicative form of affranchise.
AFFRANCHISE v. to free from slavery or similar obligation.
AFFRICATIVESaffricatives n. Plural of affricative.
AFFRICATIVE n. a sound like an affricate.
AIRCRAFTSMENaircraftsmen n. Plural of aircraftsman.
AIRCRAFTSMAN n. a member of the lowest (male) rank in the RAF, also AIRCRAFTMAN.
CLAMJAMFRIESCLAMJAMFRY n. (Scots) rubbish, nonsense, also CLAMJAMPHRIE, CLANJAMFRAY.
FACTIONARIESfactionaries n. Plural of factionary.
FACTIONARY n. a member of a faction.
FARCICALNESSfarcicalness n. The property of being farcical.
FARCICALNESS n. the state of being farcical.
FRACTALITIESFRACTALITY n. the state of being fractal.
FRACTIONATESfractionates v. Third-person singular simple present indicative form of fractionate.
FRACTIONATE v. to separate a mixture into different portions esp. by a fractional process.
INFRACLASSESinfraclasses n. Plural of infraclass.
PARFOCALISEDPARFOCALISE v. to make parfocal, also PARFOCALIZE.
PARFOCALISESPARFOCALISE v. to make parfocal, also PARFOCALIZE.
PARFOCALIZESparfocalizes v. Third-person singular simple present indicative form of parfocalize.
PARFOCALIZE v. to make parfocal, also PARFOCALISE.
RAREFACTIONSrarefactions n. Plural of rarefaction.
RAREFACTION n. the act of rarefying.
REFRACTARIESREFRACTARY n. a substance that is able to resist high temperatures, etc., used in lining furnaces, etc.
SACCHARIFIEDsaccharified v. Simple past tense and past participle of saccharify.
saccharified adj. Converted into simple sugars.
SACCHARIFY v. to convert into, or to impregnate with, sugar.
SACCHARIFIESsaccharifies v. Third-person singular simple present indicative form of saccharify.
SACCHARIFY v. to convert into, or to impregnate with, sugar.
SAFECRACKINGsafecracking n. The act of defeating the security mechanisms of a safe or vault to gain access to its contents.
SAFECRACKING n. the act of breaking open a safe.
SPACEFARINGSSPACEFARING n. voyaging in space.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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