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There are 20 words containing A, 2D, E, 2M and S

MANDAMUSEDmandamused v. Simple past tense and past participle of mandamus.
MANDAMUS v. (Latin) to command by writ from a higher court to a lower.
DUMMELHEADSDUMMELHEAD n. (dialect) a stupid person.
MACADAMISEDmacadamised v. Simple past tense and past participle of macadamise.
MACADAMISE v. to cover a road with small broken stones, also MACADAMIZE.
MIDDLEGAMESmiddlegames n. Plural of middlegame.
middle␣games n. Plural of middle game.
MISDEMEANEDmisdemeaned v. Simple past tense and past participle of misdemean.
MISDEMEAN v. to behave ill, with a reflexive pronoun; as, to misdemean one's self.
MASTERMINDEDmasterminded v. Simple past tense and past participle of mastermind.
MASTERMIND v. to originate, think out, and direct.
DEMIMONDAINESdemimondaines n. Plural of demimondaine.
demi-mondaines n. Plural of demi-mondaine.
DEMIMONDAINE n. (French) a demirep, a woman of doubtful reputation.
UNMACADAMISEDunmacadamised adj. Alternative form of unmacadamized.
UNMACADAMISED adj. not macadamised, also UNMACADAMIZED.
CHORDAMESODERMchordamesoderm n. (Anatomy) The axial mesoderm, which lies along the central axis under the neural tube and gives rise to the notochord.
CHORDAMESODERM n. the layer of specialized cells in the middle of a developing embryo which forms the notochord and structures of the central nervous system.
DISACCOMMODATEdisaccommodate v. (Transitive) To put to inconvenience; to incommode.
DISACCOMMODATE v. to put to inconvenience.
DISCOMMENDABLEdiscommendable adj. Deserving disapprobation or blame.
DISCOMMENDABLE adj. that can be discommended.
LAMPADEDROMIESLAMPADEDROMY n. a foot race with lighted torches, esp. a relay race in which the torch is passed on, also LAMPADEPHORIA.
MELODRAMATISEDmelodramatised v. Simple past tense and past participle of melodramatise.
MELODRAMATISE v. to make melodramatic, also MELODRAMATIZE.
SLEDGEHAMMEREDsledgehammered v. Simple past tense and past participle of sledgehammer.
SLEDGEHAMMER v. to strike with a sledgehammer.
CHLAMYDOMONADESCHLAMYDOMONAS n. a member of the genus Chlamydomonas of (mainly freshwater) green algae.
CHORDAMESODERMSCHORDAMESODERM n. the layer of specialized cells in the middle of a developing embryo which forms the notochord and structures of the central nervous system.
DISACCOMMODATEDdisaccommodated v. Simple past tense and past participle of disaccommodate.
DISACCOMMODATE v. to put to inconvenience.
DISACCOMMODATESdisaccommodates v. Third-person singular simple present indicative form of disaccommodate.
DISACCOMMODATE v. to put to inconvenience.
DISCOMMENDATIONdiscommendation n. (Archaic) blame; censure; reproach; shunning.
DISCOMMENDATION n. the act of discommending.
MALADMINISTEREDmaladministered v. Simple past tense and past participle of maladminister.
MALADMINISTER v. to administer wrongly.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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