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There are 4 words containing 2A, 2O, P and 2U

AUTOPHAGOUSautophagous adj. Self-eating; exhibiting autophagy.
AUTOPHAGOUS adj. related to autophagy, sustenance by self-absorption of the tissues of the body.
AUTOPHANOUSautophanous adj. (Rare) Producing its own light.
AUTOPHANOUS adj. self-luminous.
AUTOCEPHALOUSautocephalous adj. (Christianity, of a church) Fully independent of the authority of any other church.
autocephalous adj. (Christianity, of a bishop) Presiding over an autocephalous church.
autocephalous adj. (Comparable) Independent; self-directed.
PORTULACACEOUSportulacaceous adj. (Botany) Of or relating to the family Portulacaceae of plants including the spring beauty.
PORTULACACEOUS adj. belonging to the leek family.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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