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There are 4 words containing 2A, 2O, 2P and X

OPOPANAXopopanax n. (Obsolete) A gum resin obtained from the root of Opopanax chironium, formerly used in medicine.
opopanax n. A perfume made from the gum resin of various trees.
opopanax n. The popinac or opopanax tree (Acacia farnesiana, syn. Vachellia farnesiana), an acacia of America.
OPOPANAXESopopanaxes n. Plural of opopanax.
OPOPANAX n. (Greek) a medicinal gum-resin.
APPROXIMATIONapproximation n. The act, process or result of approximating.
approximation n. (Mathematics) An imprecise solution or result that is adequate for a defined purpose.
approximation n. (Medicine) The act of bringing together the edges of tissue to be sutured.
APPROXIMATIONSapproximations n. Plural of approximation.
APPROXIMATION n. the act of drawing together.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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