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There are 14 words containing 2A, 2D, 2E and F

DECAFFEINATEDdecaffeinated adj. From which caffeine has been removed (e.g. decaffeinated coffee).
DECAFFEINATE v. to remove caffeine from.
DEFAECATEDdefaecated v. Simple past tense and past participle of defaecate.
defæcated v. Obsolete spelling of defecated; simple past tense and past participle of defæcate.
DEFAECATE v. to void excrement, also DEFECATE.
DEFALCATEDdefalcated v. Simple past tense and past participle of defalcate.
DEFALCATE v. to embezzle money held on trust.
DEFAMILIARIZEDdefamiliarized v. Simple past tense and past participle of defamiliarize.
DEFEASANCEDdefeasanced adj. (Law) Liable to defeasance; capable of being made void or forfeited.
DEFEASANCED adj. liable to be forfeited.
DEFLAGRATEDdeflagrated v. Simple past tense and past participle of deflagrate.
DEFLAGRATE v. to burn suddenly, generally with flame and crackling noise.
FALDERALEDFALDERAL v. to sing meaningless sounds, also FALDEROL, FOLDEROL.
FATHEADEDfatheaded adj. Characteristic of a fathead; stupid.
FATHEADED adj. stupid.
FATHEADEDLYfatheadedly adv. Stupidly.
FATHEADED adv. stupid.
FATHEADEDNESSfatheadedness n. The quality of being fatheaded.
FATHEADED n. stupid.
FATHEADEDNESSESFATHEADEDNESS n. FATHEADED, stupid.
FEATHERHEADEDfeatherheaded adj. Alternative form of feather-headed.
feather-headed adj. (Colloquial) giddy; frivolous; foolish.
FEATHERHEADED adj. foolish, empty-headed.
GRANDFATHEREDgrandfathered v. Simple past tense and past participle of grandfather.
GRANDFATHER v. to exempt (an activity, person, etc.) from a new piece of legislation, restriction or the like.
SAFEGUARDEDsafeguarded v. Simple past tense and past participle of safeguard.
safe-guarded v. Simple past tense and past participle of safe-guard.
SAFEGUARD v. to keep safe.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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