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There are 4 eight-letter words containing A, C, 2E, F, I and N

CAFFEINEcaffeine n. An alkaloid, C8H10N4O2, found naturally in tea and coffee plants which acts as a mild stimulant on the…
CAFFEINE n. a bitter alkaloid used as a stimulant, also CAFFEIN.
DEFIANCEdefiance n. The feeling, or spirit of being defiant.
defiance n. Open or bold resistance to or disregard for authority, opposition, or power.
defiance n. A challenging attitude or behaviour; challenge.
FAIENCESfaiences n. Plural of faience.
faïences n. Plural of faïence.
FAIENCE n. (French) a type of glazed pottery, also FAYENCE.
FIANCEESfiancees n. Plural of fiancee.
fiancées n. Plural of fiancée.
FIANCEE n. (French) a woman engaged to be married.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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