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There are 4 eight-letter words containing 2A, D, E, M, S and T

ADAMSITEadamsite n. An organic compound, diphenylaminechlorarsine, used as a riot-control agent.
Adamsite n. (US politics, historical) A supporter of John Quincy Adams (1767–1848), American statesman who served…
ADAMSITE n. a lung-irritating gas.
DIASTEMAdiastema n. (Pathology) A gap or space between two adjacent teeth, especially the upper front incisors (in humans).
diastema n. (Pathology) any abnormal space, fissure, or cleft in an organ or part of the body.
diastema n. (Cytology) the modified protoplasm at the equator of a cell, existing before mitotic division.
MANDATESmandates n. Plural of mandate.
mandates v. Third-person singular simple present indicative form of mandate.
man␣dates n. Plural of man date.
MASTHEADmasthead n. (Nautical) The top of a mast.
masthead n. (US) A list of a newspaper or other periodical’s main staff, contributing writers, publisher, circulation…
masthead n. (UK, Australia) The title (normally in a large and distinctive font) of a newspaper or other periodical…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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