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There are 5 twelve-letter words containing A, C, 3S and 2U

ACUPRESSURESacupressures n. Plural of acupressure.
ACUPRESSURE n. the application of pressure to discrete points on the body for therapeutic effects.
CAUTIOUSNESScautiousness n. The state of being cautious; wariness.
CAUTIOUSNESS n. the state of being cautious.
GLAUCOUSNESSglaucousness n. The quality of being glaucous.
GLAUCOUSNESS n. the state of being glaucous.
SUBSCAPULARSsubscapulars n. Plural of subscapular.
SUBSCAPULAR n. a subscapular vessel or nerve.
SUCCUSSATIONsuccussation n. (Obsolete) Violent shaking or jolting.
succussation n. (Obsolete) A trot or trotting.
SUCCUSSATION n. a violent shaking.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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