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There are 6 twelve-letter words containing A, C, F, 2R and 2U

FLUOROURACILfluorouracil n. (Pharmacology) A fluorine-substituted derivative of uracil C4H3FN2O2 which inhibits DNA synthesis and…
FLUOROURACIL n. a fluorine-containing pyrimidine base used as a neoplastic agent to treat some kinds of cancer.
FURFURACEOUSfurfuraceous adj. Made of bran.
furfuraceous adj. Resembling bran; having or characterised by small flakes that resemble bran; resembling dandruff.
FURFURACEOUS adj. containing bran or particles resembling bran, also FURFUROUS.
MANUFACTURERmanufacturer n. A person or company that manufactures.
MANUFACTURER n. one that manufactures.
ULTRACAREFULultracareful adj. Extremely careful.
ULTRACAREFUL adj. very very careful.
UNDERSURFACEundersurface n. The underneath surface; the bottom, or underside.
UNDERSURFACE n. an underside.
USUFRUCTUARYusufructuary adj. (Law) Of or pertaining to a usufruct.
usufructuary n. (Law) A person who holds property, or the use of assets, by usufruct; a fructuary.
USUFRUCTUARY n. a person who has the use or enjoyment of something, esp. property.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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