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There are 7 twelve-letter words containing A, 2C, N, S and 2U

ACUPUNCTURESacupunctures n. Plural of acupuncture.
acupunctures v. Third-person singular simple present indicative form of acupuncture.
ACUPUNCTURE n. the complementary therapy of puncturing the skin with needles at specified points in order to cure illness.
CONTUMACIOUScontumacious adj. Contemptuous of authority; willfully disobedient; rebellious.
contumacious adj. (Law) Willfully disobedient to the summons or orders of a court.
CONTUMACIOUS adj. stubbornly disobedient, rebellious.
MACRONUCLEUSmacronucleus n. (Biology) The larger of the two nuclei present in ciliate protozoans; it controls the nonreproductive…
MACRONUCLEUS n. a relatively large densely staining nucleus of most ciliate protozoans that is derived from micronuclei and controls various nonreproductive functions.
SUCCEDANEOUSsuccedaneous adj. Pertaining to, or acting as, a succedaneum; supplying the place of something else; being, or employed…
SUCCEDANEOUS adj. subrogated, substituted.
SUCCEDANEUMSsuccedaneums n. Plural of succedaneum.
SUCCEDANEUM n. (Latin) a substitute; a remedy.
SUCCUSSATIONsuccussation n. (Obsolete) Violent shaking or jolting.
succussation n. (Obsolete) A trot or trotting.
SUCCUSSATION n. a violent shaking.
UNACCUSTOMEDunaccustomed adj. Not used to an event or thing, not accustomed.
unaccustomed v. Simple past tense and past participle of unaccustom.
UNACCUSTOMED adj. not customary.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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