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There are 4 twelve-letter words containing 2A, 2M and 3S

ASTIGMATISMSastigmatisms n. Plural of astigmatism.
ASTIGMATISM n. a defect in the eye or a lens by which rays from a single source are not focused at a single point, also ASTIGMIA.
IMMUNOASSAYSimmunoassays n. Plural of immunoassay.
IMMUNOASSAY n. the determination of the presence and quantity of a substance through its action as an antigen.
PLASMODESMASplasmodesmas n. Plural of plasmodesma.
PLASMODESMA n. a strand of living cytoplasm connecting two cells, also PLASMODESM.
SOMATOPLASMSsomatoplasms n. Plural of somatoplasm.
SOMATOPLASM n. protoplasm of the somatic cells.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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