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There are 5 twelve-letter words containing 2A, 2D and 3E

ACETALDEHYDEacetaldehyde n. (Organic chemistry) An organic compound, (CH3CHO). Sometimes called ethanal or acetic aldehyde. See…
ACETALDEHYDE n. a chemical compound.
DEPAUPERATEDdepauperated v. Simple past tense and past participle of depauperate.
DEPAUPERATE v. to impoverish.
HAMMERHEADEDhammerheaded adj. Alternative form of hammer-headed.
hammer-headed adj. Having a head in the shape of a hammer.
hammer-headed adj. (Idiomatic) stupid, ignorant.
HENDECAHEDRAhendecahedra n. Plural of hendecahedron.
HENDECAHEDRON n. a solid figure having 11 plane faces.
SPREADEAGLEDspreadeagled v. Simple past tense and past participle of spreadeagle.
spread-eagled v. Simple past tense and past participle of spread-eagle.
spread-eagled adj. In a spread eagle position.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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