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There are 8 twelve-letter words containing 2A, C, E, S and 2U

ACCULTURATESacculturates v. Third-person singular simple present indicative form of acculturate.
ACCULTURATE v. to undergo acculturation.
AMPULLACEOUSampullaceous adj. Shaped like a swollen bottle.
AMPULLACEOUS adj. of or like an ampulla, also AMPULLACEAL.
AQUACULTURESaquacultures n. Plural of aquaculture.
AQUACULTURE n. the practice of using the sea, lakes etc. for fish-farming, also AQUICULTURE.
AUSCULTATIVEauscultative adj. Relating to auscultation.
AUSCULTATIVE adj. related to auscultation, also AUSCULTATORY.
MANUFACTURESmanufactures n. Plural of manufacture.
manufactures v. Third-person singular simple present indicative form of manufacture.
MANUFACTURE v. to make into a product suitable for use.
SUPERNACULARsupernacular adj. (Obsolete, humorous, of alcoholic drink) Of outstanding quality; that one would wish to drink to the last drop.
SUPERNACULAR adj. very good; first rate.
SUSTENTACULAsustentacula n. Plural of sustentaculum.
SUSTENTACULUM n. a supporting part or structure.
VASCULATURESvasculatures n. Plural of vasculature.
VASCULATURE n. the arrangement of blood vessels.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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