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There are 11 twelve-letter words containing 2A, C, 2E, F and S

CALEFACIENTScalefacients n. Plural of calefacient.
CALEFACIENT n. a substance (e.g. mustard) that produces a sensation of warmth when applied to a part of the body.
DEFAECATIONSdefaecations n. Plural of defaecation.
defæcations n. Plural of defæcation.
DEFAECATION n. the expulsion of solid waste from the body, also DEFECATION.
FORBEARANCESforbearances n. Plural of forbearance.
FORBEARANCE n. tolerance.
FORECASTABLEforecastable adj. Capable of being forecast; predictable.
FORECASTABLE adj. that can be forecast.
MALEFACTRESSmalefactress n. A woman who violates the law or does evil; a female malefactor.
MALEFACTRESS n. a female malefactor.
MALFEASANCESmalfeasances n. Plural of malfeasance.
MALFEASANCE n. the performance by a public official of an act that is legally unjustified, harmful, or contrary to law; wrongdoing (used especially of an act in violation of a public trust), also MISFEASANCE.
MISFEASANCESmisfeasances n. Plural of misfeasance.
MISFEASANCE n. the performance by a public official of an act that is legally unjustified, harmful, or contrary to law; wrongdoing (used especially of an act in violation of a public trust), also MALFEASANCE.
NONFEASANCESnonfeasances n. Plural of nonfeasance.
NONFEASANCE n. failure to perform an act or obligation.
REFRACTARIESREFRACTARY n. a substance that is able to resist high temperatures, etc., used in lining furnaces, etc.
SAFECRACKERSsafecrackers n. Plural of safecracker.
safe-crackers n. Plural of safe-cracker.
SAFECRACKER n. one that breaks open safes to steal.
SHAMEFACEDLYshamefacedly adv. In a shamefaced manner.
SHAMEFACED adv. showing modesty, also SHAMEFAST.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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