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There are 8 twelve-letter words containing 2A, C, D, E and 2P

APPENDICULARappendicular adj. Of or pertaining to a limb or appendage.
appendicular adj. Of or pertaining to the appendix.
APPENDICULAR adj. of or relating to an appendage and esp. a limb.
CEPHALOPODANCEPHALOPODAN n. any marine mollusc of the class Cephalopoda, that includes the octopuses, squids, cuttlefish, and pearly nautilus, also CEPHALOPOD.
CLAPPERBOARDclapperboard n. (Film) A device used in film production, having hinged boards that are brought together with a clap…
clapper␣board n. (Film) Alternative form of clapperboard.
CLAPPERBOARD n. a hinged board (or a set of hinged boards) clapped together in front of the camera before or after shooting a piece of film, to help synchronize sound and vision.
HANDICAPPERShandicappers n. Plural of handicapper.
HANDICAPPER n. a person who assigns handicaps.
PAEDOPHILIACpaedophiliac n. A person who is sexually attracted to children; a paedophile.
paedophiliac adj. Relating to paedophilia or to a paedophile.
pædophiliac adj. Alternative spelling of paedophiliac.
PARAPERIODICPARAPERIODIC adj. as in paraperiodic acid.
PARTICIPATEDparticipated v. Simple past tense and past participle of participate.
PARTICIPATE v. to take part in.
UNAPPROACHEDunapproached adj. Not approached.
UNAPPROACHED adj. not approached.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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