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There are 4 twelve-letter words containing 2A, B, F, G, L and R

FIBROMYALGIAfibromyalgia n. (Medicine, pathology) A condition characterised by chronic pain, stiffness, and tenderness of the muscles…
FIBROMYALGIA n. any of a group of rheumatic disorders affecting soft tissues.
FLABBERGASTSflabbergasts n. Plural of flabbergast.
flabbergasts v. Third-person singular simple present indicative form of flabbergast.
FLABBERGAST v. to overwhelm with shock, surprise, or wonder.
IRREFRAGABLEirrefragable adj. Which cannot be refuted; clearly right, incontrovertible, indisputable, irrefutable.
irrefragable adj. (Archaic) Which cannot or should not be broken; indestructible.
irrefragable adj. (Obsolete) Of a person: obstinate, stubborn.
IRREFRAGABLYirrefragably adv. In an irrefragable state or condition.
IRREFRAGABLE adv. impossible to refute or dispute.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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