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There are 4 eight-letter words containing 2A, N, O, T and X

ANATOXINanatoxin n. A bacterial toxin (usually an exotoxin) whose toxicity has been weakened or suppressed.
anatoxin n. A powerful neurotoxin, one of many toxins produced by several species of cyanobacterium.
ANATOXIN n. a potent alkaloid toxin derived from a species of cyanobacteria.
LAXATIONlaxation n. The act of loosening or slackening, or the state of being loosened or slackened.
laxation n. Defecation.
LAXATION n. the act of loosening or slackening.
TAXATIONtaxation n. The act of imposing taxes and the fact of being taxed.
taxation n. A particular system of taxing people or companies.
taxation n. The revenue gained from taxes.
XANTHOMAxanthoma n. (Medicine) A small, yellow nodule, rich in cholesterol and other lipids, that occurs in the skin, often near a joint.
XANTHOMA n. a skin disease marked by the development of irregular yellowish patches upon the skin, esp. upon the eyelids.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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