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There are 13 eight-letter words containing 2A, C, D and 2E

ACADEMESacademes n. Plural of academe.
ACADEME n. the academic life or world, also ACADEMIA.
ACERATEDacerated adj. Synonym of acerate.
ACERATED adj. needle-shaped, also ACERATE.
ACETATEDacetated adj. (Chemistry) Combined with acetic acid.
ACETATED adj. combined with acetic acid.
AREACHEDareached v. Simple past tense and past participle of areach.
AREACH v. (Spenser) to reach.
CASEATEDcaseated v. Simple past tense and past participle of caseate.
CASEATE v. to become cheesy.
CAVEATEDcaveated v. Simple past tense and past participle of caveat.
CAVEAT v. (Latin) to enter a type of legal notice.
ECAUDATEecaudate adj. (Biology) Tailless; without a tail or tail-like appendage.
ECAUDATE adj. tailless, also ACAUDAL, ACAUDATE.
ESCALADEescalade n. An act of scaling walls or fortifications.
escalade v. (Military, dated) To scale the walls of a fortification.
ESCALADE v. (French) to scale the walls of a fortress by ladders, also ESCALADO, SCALADE, SCALADO.
ESCAPADEescapade n. A daring or adventurous act; an undertaking which goes against convention.
ESCAPADE n. a reckless adventure.
ESTACADEestacade n. (Military) A dike of piles in the sea, a river, etc., to hinder the approach of an enemy.
ESTACADE n. (French) a dike of stakes in a river against an enemy.
HEADACHEheadache n. A pain or ache in the head.
headache n. (Figurative) A nuisance or unpleasant problem.
head-ache n. Archaic form of headache.
HEADCASEheadcase n. (Informal, derogatory) A mentally unbalanced, unpredictable person, especially one who displays aggressive behavior.
headcase n. (Genetics) A genetic sequence that inhibits terminal branching of the trachea and regulates dendrite pruning.
head-case n. Alternative spelling of headcase.
HEADRACEheadrace n. The part of a millrace that brings water to the millwheel.
headrace n. A time trial in the sport of rowing.
head-race n. Alternative form of headrace.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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