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There are 19 twelve-letter words containing 2A, O, 2T and X

ANTHOXANTHINanthoxanthin n. (Biochemistry) Any of a group of water-soluble flavonoid pigments found in plants.
ANTHOXANTHIN n. a yellow pigment in plants.
ANTIOXIDANTSantioxidants n. Plural of antioxidant.
ANTIOXIDANT n. a substance (as betacarotene or vitamin C) that inhibits oxidation.
AUTOTOXAEMIAautotoxaemia n. Autointoxication.
auto-toxaemia n. Alternative spelling of autotoxaemia.
AUTOTOXAEMIA n. self-poisoning caused by absorption of toxic products originating within the body, also AUTOTOXEMIA.
AUTOTOXEMIASautotoxemias n. Plural of autotoxemia.
AUTOTOXEMIA n. self-poisoning caused by absorption of toxic products originating within the body, also AUTOTOXAEMIA.
AUTOXIDATIONautoxidation n. (Chemistry) A spontaneous oxidation reaction that results in the slow, flameless combustion of a material.
AUTOXIDATION n. oxidation by direct combination with oxygen at ordinary temperatures.
EXPATIATIONSexpatiations n. Plural of expatiation.
EXPATIATION n. the act of expatiating.
EXPATRIATIONexpatriation n. Voluntary migration from one’s native land to another.
expatriation n. Forced expulsion of from one’s native land to another.
EXPATRIATION n. the act of expatriating.
EXPLANTATIONexplantation n. The act of explanting.
EXPLANTATION n. the act of explanting.
EXTRAPOLATEDextrapolated v. Simple past tense and past participle of extrapolate.
EXTRAPOLATE v. to infer (values of a variable in an unobserved interval) from values within an already observed interval.
EXTRAPOLATESextrapolates v. Third-person singular simple present indicative form of extrapolate.
EXTRAPOLATE v. to infer (values of a variable in an unobserved interval) from values within an already observed interval.
EXTRAPOLATORextrapolator n. That which extrapolates.
EXTRAPOLATOR n. one who extrapolates.
HETEROTAXIASHETEROTAXIA n. the abnormal disposition of organs or parts, also HETEROTAXY.
METATHORAXESmetathoraxes n. Plural of metathorax.
METATHORAX n. the last or posterior segment of the thorax in insects.
OVERTAXATIONovertaxation n. Excessive taxation.
OVERTAXATION n. excessive taxation.
OXALACETATESoxalacetates n. Plural of oxalacetate.
OXALACETATE n. a salt or ester of oxaloacetic acid, also OXALOACETATE.
OXALOACETATEoxaloacetate n. (Organic chemistry) any salt or ester of oxaloacetic acid.
OXALOACETATE n. a salt or ester of oxaloacetic acid, also OXALACETATE.
PORTMANTEAUXportmanteaux n. Plural of portmanteau.
PORTMANTEAU n. (French) a case opening in two parts, used for carrying clothes while traveling, also PORTMANTLE, PORTMANTUA.
STEREOTAXIASSTEREOTAXIA n. the electrical destruction of a small area of brain tissue, using stereotactic methods, to relieve disorders such as epilepsy and Parkinsonism.
XANTHOMATOUSxanthomatous adj. Of or relating to xanthoma or xanthomatosis.
XANTHOMATOUS adj. of or like a xanthoma, a skin disease marked by the development or irregular yellowish patches upon the skin.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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