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There are 20 ten-letter words containing 2A, N, O, P and U

AMPUTATIONamputation n. Surgical removal of all or part of a limb, etc.
amputation n. The loss of a limb, etc. through trauma.
AMPUTATION n. the act of amputating.
ANATROPOUSanatropous adj. (Botany, of an ovule) Having an inverted nucleus, whose apex points to the base.
ANATROPOUS adj. of an ovule, inverted so that the micropyle is next to the stalk.
ANDROPAUSEandropause n. The male equivalent of the menopause in women; characterised by a decline in libido and overall energy.
ANDROPAUSE n. the male menopause.
AQUAPONICSaquaponics n. (Agriculture) A sustainable food production system that combines traditional aquaculture with hydroponics…
AQUAPORINSaquaporins n. Plural of aquaporin.
AQUAPORIN n. any of a group of proteins in a cell membrane that allow the passage of water across the membrane.
CANTALOUPEcantaloupe n. A melon of species Cucumis melo subsp. melo with sweet orange flesh, with numerous cultivars in several…
cantaloupe n. An orange colour, like that of cantaloupe flesh.
CANTALOUPE n. (Italian) a small musk melon with a ribbed skin, also CANTALOUP.
CANTALOUPScantaloups n. Plural of cantaloup.
CANTALOUP n. (Italian) a small musk melon with a ribbed skin, also CANTALOUPE.
DIAPHANOUSdiaphanous adj. Transparent or translucent; allowing light to pass through; capable of being seen through.
diaphanous adj. Of a fine, almost transparent, texture; gossamer; light and insubstantial.
diaphanous adj. (Physics) Isorefractive, having an identical refractive index.
MENOPAUSALmenopausal adj. Of, or pertaining to the menopause.
MENOPAUSAL adj. relating to the menopause, also MENOPAUSIC.
NATUROPATHnaturopath n. (Alternative medicine) A practitioner of naturopathy, a nature healer.
NATUROPATH n. a person who practises naturopathy.
PAPULATIONpapulation n. (Medicine) The formation of papules.
PAPULATION n. the development of papillae or pimples.
PARAMOUNCYPARAMOUNCY n. the state of being paramount, also PARAMOUNTCY.
PARAMOUNTSparamounts n. Plural of paramount.
PARAMOUNT n. an overlord; a supreme ruler or proprietor.
PAULOWNIASpaulownias n. Plural of paulownia.
PAULOWNIA n. any tree of the Chinese and Japanese genus Paulownia, of the figwort family, with showy flowers.
PORTMANTUAportmantua n. Obsolete form of portmanteau (“case”).
PORTMANTUA n. (obsolete) a portmanteau, also PORTMANTEAU, PORTMANTLE.
POZZUOLANApozzuolana n. Alternative spelling of pozzolana.
POZZUOLANA n. (Italian) volcanic ashes from Pozzuoli, in Italy, used in the manufacture of a kind of mortar which hardens under water, also POZZOLAN, POZZOLANA, PUZZOLANA.
PUZZOLANASpuzzolanas n. Plural of puzzolana.
PUZZOLANA n. (Italian) volcanic ashes from Pozzuoli, in Italy, used in the manufacture of a kind of mortar which hardens under water, also POZZOLAN, POZZOLANA, POZZUOLANA.
UNPASTORALunpastoral adj. Not pastoral.
UNPASTORAL adj. not pastoral.
VAPULATIONvapulation n. (Obsolete) The act of beating or whipping.
VAPULATION n. the act of beating or whipping.
WRAPAROUNDwraparound adj. (Of clothing) Designed to be wrapped around the body and tied.
wraparound adj. (Of windows, lenses, etc.) That extends around a corner or bend.
wraparound adj. Serving to surround or bookend something else.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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